Quant NQAD^TM Analytical Detector

Nano Quantity Analyte Detector - A New Aerosol-Based Detector The Quant NQADTM Nano Quantity Analyte Detector is a new and completely different kind of aerosol-based detector for HPLC.  Based on Condensation Nucleation (CNLSD) technology, the NQADTM detector's high sensitivity helps analytical chemists accurately identify and measure extremely low concentrations of compounds in low nanogram ranges. The NQADTM detector also offers a wide dynamic range with superior linearity when compared to other aerosol-based detectors.  Universal detection of a broad range of semivolatile and nonvolatile compounds provides accurate concentration analysis of the drug components.  This superior performance will aid pharmaceutical development where impurities or drug degradation can be detected with minimal sample preparation.

What Makes the NQAD^TM Detector Better?

Broad Range of Analytes 

Ultra-Sensitivity at Low Nanogram Levels 

Wide Dynamic Range 

Linear Response 

Reproducible Results 

Small Size, Robust, Reliable 

Easy Set-Up and Operation 

Broad Range of Analytes

The detection of the NQAD^TM detector is near universal for compounds that are less volatile than the mobile phase. Chromophores and fluorophores are not needed for detection, thereby eliminating or decreasing the need for compound derivertization. This figure shows five different groups of compounds detected by the  detector . Run time for the analyses ranged from 5 to 15 minutes. The detector’s fast response time produces narrow peaks for more accurate quantification and enhanced resolution.

Ultra-Sensitive to Low Nanogram Levels

With the ability to detect sub-nanogram levels, the  detector’s ultra-high sensitivity can be used when only trace amount of analytes are available. The  detector is ideal for searching for drug impurities, degradation products, excipients and when industrial hygiene is a concern. Both previously easy and hard-to-measure compounds can be quantified accurately with minimal sample preparation. Shown here are 0.5 ng cation concentrations with peaks that have signal-to-noise ratios higher than 10:1.

Wide Dynamic Range

The wide dynamic range shows a linear response covering over four orders of magnitude. With this wide range less sample preparation time is required and more information is obtained from a single sample solution injection.

Linear Response

The  detector shows superior linearity compared to other aerosol-based detectors, covering several orders of magnitude for most analytes. When you combine its sensitivity and linear responsiveness, multiple sample preparation is often not necessary; only one sample preparation may be used for the main drug compound, impurities and/or degradation products analysis. Only one method validation for both the main drug compound and other compounds present in trace amounts is required. This figure shows a portion of Sucrose linearity range.

Reproducible Results

Detector response is stable, precise and reproducible for reliable results. To demonstrate this, six chromatograms of a solution containing Li+, Na+, and K+ were obtained on different days and compared. The figure demonstrates the closeness of the detector responses on different days; they are identical.

Small Size, Robust, Reliable

Weighing in at just 20lbs (9.1 kg) and with a footprint of just 6 inches x 17 inches (15.5 cm x 43 cm), the  detector is quite possibly the smallest HPLC detector on the market.  But don't let its diminutive stature fool you.  Packed inside is more of everything you're looking for - sensitivity, dynamic range, linearity, reproducibility, universal detection - all at an affordable price.  Each instrument is expertly built with the quality commitment of Quant Technologies.

Easy Set-Up and Operation

"I was able to set up this new  detector in less than one hour and the control/screen panel was very easy to navigate."
- Donald S. Risley, beta-tester