Grace has developed MS-compatible LC methods for Melamine using an HILIC media platform that can be applied to both traditional HPLC as well as UHPLC systems. Melamine was analyzed with a standard HPLC system using a 5μm particle HILIC phase packed into a 250 x 4.6mm column. The 1.5μm version of this phase was then packed into a high throughput format conducive to UHPLC and fast LC systems. Both methods deliver excellent linearity and use isocratic elution for fast analysis without the need for re-equilibration.